LEGAL REGIME OF CREATION OF A SECURE DIGITAL EDUCATIONAL ENVIRONMENT


The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes

Summary: Impaired bone quality and increased fracture Canteen risk are cardinal features of the skeleton in diabetes mellitus.Hyperglycemia-induced oxidative stress is proposed as a potential underlying mechanism, but the precise pathogenic mechanism remains incompletely understood.In this investigation, osteoblasts under high glucose exhibited hei

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Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Abstract Background Thrombotic events cannot be completely prevented by antithrombotics, implicating a therapeutic gap due to inflammation, a Tilt not yet sufficiently addressed mechanism.Neutrophil extracellular traps (NETs) are an essential interface between inflammation and thrombosis, but exactly how the NETotic process is initiated and maintai

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